Glaucoma and vision loss linked to increased depression risk: Study highlights need for mental health support

Individuals with primary open-angle glaucoma, particularly those with vision impairment, are at a significantly higher risk of developing depression, according to a study that highlights the importance of addressing mental health in patients with glaucoma, especially those experiencing vision loss.

A nationwide, population-based cohort study was conducted using data from the Korean National Health Information Database and National Disability Registry. Baseline characteristics, including demographic, lifestyle, and clinical factors, were assessed. The relationship between glaucoma, vision impairment, and depression risk was analyzed using a multivariable-adjusted Cox proportional hazard model.

Of the 3.68 million participants from the 2009 Korean National Health Screening Program, 681,515 developed depression during the follow-up. Individuals with glaucoma had an elevated risk of developing depression, with an adjusted hazard ratio (HR) of 1.085. The risk further increased in those with vision impairment, rising to an adjusted HR of 1.164 for mild vision impairment and 1.207 for severe vision impairment. The association was stronger in men and in individuals with fewer comorbidities.

Reference
Wang SM, Jung Y, Han K, et al. Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study. Heliyon. 2024;11(1):e40617. doi: 10.1016/j.heliyon.2024.e40617. PMID: 39758387; PMCID: PMC11699410.