Genetic evidence suggests that aspirin use is associated with a higher risk of early and dry age-related macular degeneration (AMD), according to a Mendelian randomization study.
The analysis showed that aspirin use was associated with a higher risk of both early and dry AMD. Further mediation analyses found that aspirin use was linked to lower serum low-density lipoprotein cholesterol (LDL-C) levels and higher serum apolipoprotein A1 (APOA1) concentrations, both of which were associated with increased AMD risk.
When researchers adjusted for LDL-C and APOA1 in multivariable analyses, the association between aspirin use and AMD was no longer statistically significant.
Reference
Zhu J, Zeng C, Tang R, et al. Causal relationship between aspirin use and age-related macular degeneration. Eye (Lond). 2026;doi: 10.1038/s41433-026-04574-2. Epub ahead of print. PMID: 42215633.
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