Glaucoma is statistically significantly associated with anxiety, major depressive disorder, and schizophrenia, according to a study.
A cross-sectional analysis of data from the Medical Expenditure Panel Survey examined the association between glaucoma and several mental health disorders. The study included 65,140 adults, with focused analyses on 15,016 individuals diagnosed with glaucoma or specific mental health conditions.
Among the full cohort, 1,492 individuals had glaucoma, while diagnoses of anxiety, major depressive disorder (MDD), bipolar disorder, and schizophrenia were identified in 6,359, 5,756, 786, and 209 individuals, respectively. Within the glaucoma group, 13.2% had anxiety, 12.2% had MDD, 1.3% had bipolar disorder, and 1.0% had schizophrenia.
Unadjusted analyses showed statistically significant associations between glaucoma and anxiety, MDD, and schizophrenia, but not bipolar disorder. After adjusting for confounding factors, the associations with anxiety, MDD, and schizophrenia remained statistically significant.
Interaction analyses evaluating race did not demonstrate significant effect measure modification for MDD, anxiety, or schizophrenia when comparing Black and non-Black populations after Bonferroni correction.
Reference
Delsoz M, Raja H, Hussain ZS, et al. Association Between Glaucoma and Mental Health Disorders Based on a Large National Database. J Ophthalmic Vis Res. 2025;20:10.18502/jovr.v20.17535. doi: 10.18502/jovr.v20.17535. PMID: 41522813; PMCID: PMC12784428.
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