Tamarind seed polysaccharide (TSP) and Hyaluronic acid (HA) eye drops are most effective when used before exposure to dry environmental conditions, offering superior protection against dry eye symptoms and maintaining tear osmolarity compared to using them after exposure, according to a study.
Researchers tested the drops in a controlled environmental chamber with 12 participants exposed to extremely low humidity (5%) and moderate temperatures (21°C).
The study evaluated treatments for protection, where the drops were instilled before exposure, and relief, where the drops were applied after exposure.
Key Findings:
- Tear osmolarity showed minimal changes, with averages of 296.0 mOsm/L (protection) and 292.0 mOsm/L (relief).
- Tear production increased significantly in both treatment modes.
- Symptom severity dropped markedly after using the drops, with greater improvement seen in the protection group.
- OST remained stable regardless of treatment.
The study concluded that using TSP/HA eye drops before exposure offers superior benefits in maintaining tear osmolarity and reducing discomfort. Although promising, the findings are limited by the small sample size, and further research is recommended.
Reference
Alotaibi WM, Abusharha A, Pearce EI, et al. Assessment of Tamarind Seed Polysaccharide (TSP) and Hyaluronic Acid (HA) Containing Ophthalmic Solution to Maintain Tear Osmolarity, Ocular Surface Temperature (OST) and Tear Production. Clin Ophthalmol. 2024;18:3503-3513. doi: 10.2147/OPTH.S493336. PMID: 39624258; PMCID: PMC11610392.
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