A recent study assessed the diagnostic performance of the InflammaDry test for dry eye disease (DED) using different diagnostic criteria and severity levels.
Researchers analyzed data from 1,515 patients, classifying them into those diagnosed with DED based on Dry Eye Workshop-II (DEWS-II) criteria, those diagnosed using criteria from previous clinical trials, and a healthy control group.
The study found that InflammaDry had higher sensitivity (81.3%) when using past clinical trial criteria but dropped to 69.99% under DEWS-II guidelines. Specificity remained low at 38.16% in both groups, with a high rate of false negatives.
These findings suggest that while InflammaDry is useful in detecting inflammation in severe DED cases, it may not be reliable for broader diagnostic use, particularly in milder forms of the disease.
Reference
Mejía-Salgado G, Rojas-Carabali W, Cifuentes-González C, et al. Real-world performance of the inflammadry test in dry eye diagnosis: an analysis of 1,515 patients. Graefes Arch Clin Exp Ophthalmol. 2025;doi: 10.1007/s00417-025-06760-6. Epub ahead of print. PMID: 40042683.
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