Best of 2025: Expanding strategies for complex neurotrophic disease
Our most-read coverage of 2025 highlights how clinicians are broadening the therapeutic toolkit for managing neurotrophic keratitis. From real-world integration of disease-modifying medical therapy to strategic use of cryopreserved amniotic membrane and minimally invasive surgical innovation, these articles underscore a shift toward earlier, more comprehensive approaches to preserving corneal health and vision.
Spotlight on Oxervate
Neurotrophic keratitis remains a challenging, vision-threatening corneal disease, but the introduction of Oxervate (cenegermin-bkbj) has transformed treatment options by targeting the underlying nerve pathology. In this Spotlight Series article, cornea specialist Neel S. Vaidya, MD, shares real-world insights on integrating the first FDA-approved therapy for neurotrophic keratitis into clinical practice, highlighting its role in achieving corneal healing, preventing progression, and reshaping long-term management strategies.
Read the full article here.
Managing difficult-to-treat ocular surface disease with multiple cryopreserved amniotic membrane treatments
In this clinician perspective, Damon Dierker, OD, outlines how cryopreserved amniotic membrane can be used strategically—not as a last resort but as a second-line, provider-led option—to promote epithelial healing, support corneal nerve recovery, and improve long-term outcomes in patients with chronic dry eye and inflammatory risk factors.
Read the full article here.
Minimally invasive corneal neurotization improves outcomes in neurotrophic keratopathy
Minimally invasive corneal neurotization may offer a durable, effective option for treating advanced neurotrophic keratopathy, even in rural and socioeconomically disadvantaged populations, according to a retrospective study. All patients achieved sustained corneal epithelialization with significant visual acuity gains over long-term follow-up, supporting the procedure’s safety and real-world feasibility in complex, high-risk NK cases.
Read the full article here.
