Contact lens sensor data enhances glaucoma progression prediction in normal-tension glaucoma

A 24-hour contact lens sensor (CLS) the measures intraocular pressure (IOP) can provide important predictive information regarding glaucoma progression in patients with normal-tension glaucoma (NTG), according to a study.

In this single-center prospective cohort study, researchers used the Triggerfish CLS to monitor IOP in one eye for 24 hours without medication, followed by diurnal IOP assessments using Goldmann applanation tonometry. Glaucoma progression was evaluated over at least 2 years based on Humphrey visual field results and fundus photographs.

Among 79 patients, 23 experienced glaucoma progression.

Key risk factors of glaucoma progression included a smaller nocturnal ocular pulse amplitude (OPA) standard deviation, larger baseline diurnal IOP range, and the presence of optic disc hemorrhage (DH). These factors were significantly associated with glaucoma progression, with hazard ratios of 0.30/mVeq, 1.23/mmHg, and 4.37 for the presence of DH, respectively.

Reference
Higashide T, Udagawa S, Nakazawa K, et al. Prediction of glaucoma progression by 24-h contact lens sensor profile in patients with normal-tension glaucoma. Sci Rep. 2024;14(1):21564. doi: 10.1038/s41598-024-72556-z. PMID: 39284824; PMCID: PMC11405842.